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Forthcoming therapeutic perspectives for infections due to multidrug-resistant Gram-positive pathogens

G Cornaglia1, G M Rossolini

  • 1Dipartimento di Patologia, Sezione di Microbiologia, Università di Verona, Verona, Italy.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|April 2, 2009
PubMed

Insights

New antibiotics are emerging to combat multidrug-resistant Gram-positive pathogens like MRSA. These include novel glycopeptides, beta-lactams, and diaminopyrimidines to address challenging infections.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Multidrug resistance in Gram-positive pathogens presents a significant therapeutic challenge.
  • The rise of methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide-resistant enterococci necessitates new antimicrobial strategies.
  • Existing antibiotic policies have been impacted, driving the need for novel drug development.

Purpose of the Study:

  • To provide an overview of emerging antibiotic agents targeting multidrug-resistant Gram-positive pathogens.
  • To highlight new drugs in clinical practice and development pipelines.
  • To summarize recent advancements in combating difficult-to-treat Gram-positive infections.

Main Methods:

  • Review of recently introduced and pipeline antibiotics.
  • Analysis of data presented at the ESCMID Conference on multidrug-resistant Gram-positives.
  • Literature review of the latest research on anti-Gram-positive agents.

Main Results:

  • Several new antibiotics are now available for clinical use.
  • The drug development pipeline includes promising agents like dalbavancin, oritavancin, telavancin, ceftobiprole, and iclaprim.
  • These agents target key resistant Gram-positive bacteria, including MRSA.

Conclusions:

  • The pipeline for anti-Gram-positive drugs is robust, offering new hope against resistant infections.
  • Upcoming agents represent significant advancements in treating infections caused by multidrug-resistant Gram-positive pathogens.
  • Continued development is crucial to stay ahead of evolving antimicrobial resistance.

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