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Related Experiment Video

Updated: Jun 24, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Varicella zoster vaccines.

Rosella Creed¹, Anita Satyaprakash, Parisa Ravanfar

¹Center for Clinical Studies, Houston, Texas, USA. rcreed@ccstexas.com

Dermatologic Therapy

|April 2, 2009

Summary

The varicella zoster virus (VZV) vaccine has significantly reduced chickenpox and shingles. A two-dose schedule for children and a specific vaccine for older adults improve VZV prevention.

Area of Science:

Virology
Immunology
Vaccinology

Background:

Varicella zoster virus (VZV) historically caused widespread illness, mortality, and morbidity.
Primary varicella (chickenpox) and herpes zoster (shingles) reactivation posed significant public health challenges.
The introduction of the varicella vaccine has led to a notable decrease in VZV-related diseases.

Purpose of the Study:

To review the impact of varicella vaccine implementation.
To highlight the evolution of vaccination strategies for VZV.
To discuss the benefits of the zoster vaccine in older adults.

Main Methods:

Review of historical data on VZV incidence and outcomes.
Analysis of vaccine approval and recommendation timelines.

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Examination of vaccine efficacy in different age groups.

Main Results:

Significant decline in varicella incidence, morbidity, and mortality post-vaccine introduction.
Shift from a one-dose to a two-dose varicella vaccine schedule for children to address breakthrough infections.
Approval of a higher-concentration zoster vaccine for individuals aged 60 and older.

Conclusions:

The varicella vaccine has been highly effective in reducing the burden of primary varicella.
Updated vaccination schedules enhance protection against VZV.
The zoster vaccine offers a promising strategy to mitigate herpes zoster and postherpetic neuralgia in older populations.