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Related Concept Videos

Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Updated: Jun 24, 2026

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model
21:16

An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model

Published on: July 13, 2009

Sensitive skin in Europe.

L Misery1, S Boussetta, T Nocera

  • 1Department of Dermatology, University Hospital, University of Western Brittany, Brest, France. laurent.misery@chu-brest.fr

Journal of the European Academy of Dermatology and Venereology : JEADV
|April 2, 2009
PubMed
Summary
This summary is machine-generated.

Sensitive skin is a common condition affecting over a third of Europeans, with higher prevalence in Italy and France. Dermatological history may influence skin sensitivity.

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An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model
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Area of Science:

  • Dermatology
  • Epidemiology
  • Public Health

Background:

  • Sensitive skin is a prevalent condition globally.
  • Limited comparative epidemiological data exists across European countries.

Purpose of the Study:

  • To conduct an epidemiological assessment of skin sensitivity across eight European nations.
  • To identify demographic and health-related factors associated with skin sensitivity.

Main Methods:

  • An online survey was administered to 4506 individuals aged 15+ across Belgium, France, Germany, Greece, Italy, Portugal, Spain, and Switzerland.
  • Data collection focused on self-reported skin sensitivity, dermatological history, and skin type.

Main Results:

  • 38.4% of participants reported having sensitive or very sensitive skin.
  • Women reported higher rates of sensitive skin than men.
  • Higher prevalence of sensitive skin was observed in Italy and France, and was associated with a history of dermatological diseases and childhood atopic dermatitis.

Conclusions:

  • This study provides the first cross-European comparison of skin sensitivity prevalence.
  • Significant geographical variations in skin sensitivity exist within Europe.
  • Dermatological history, including atopic dermatitis, appears to be a contributing factor to skin sensitivity.