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Obstructive jaundice after bone marrow transplantation.

G R Lipshutz, R M Katon, T G Lee

Gastroenterology

|September 1, 1977

Summary

This summary is machine-generated.

Jaundice post-bone marrow transplant can signal graft-versus-host disease. This case highlights recurrent leukemia in the gastrointestinal tract as a rare cause of jaundice, even with a seemingly clear bone marrow.

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Area of Science:

Hematology
Gastroenterology
Oncology

Background:

Jaundice post-bone marrow transplantation (BMT) is often attributed to graft-versus-host disease (GVHD).
Obstructive jaundice developing months after a successful allogeneic BMT requires thorough investigation.
Gastrointestinal (GI) involvement in leukemia can mimic other post-BMT complications.

Observation:

A patient developed obstructive jaundice months after a successful allogeneic marrow transplant.
Bone marrow examination showed remission, but symptoms persisted.

Findings:

Diagnostic imaging and biopsy revealed recurrent leukemia in the pancreatic head and duodenum.
This contrasts with the typical GVHD as the cause of jaundice.

Implications:

Highlights the importance of considering gastrointestinal leukemia recurrence post-BMT, even with a non-diagnostic bone marrow.
Underscores the need for thorough gastrointestinal evaluation in BMT patients with unexplained jaundice.