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Darier disease complicated by disseminated zoster
Rajesh Kandasamy1, Michelle Hecker, Michael Choi
1Department of Medicine, Case Western Reserve University/MetroHealth Medical Center Cleveland, Ohio, USA. rkandasamy@metrohealth.org
Dermatology Online Journal
|April 2, 2009
Summary
A patient with Darier disease and kidney failure experienced disseminated Herpes Zoster. Intravenous acyclovir administered during hemodialysis effectively treated the infection.
Area of Science:
- Dermatology
- Nephrology
- Infectious Diseases
Background:
- Darier disease is a rare genetic skin disorder.
- End-stage renal failure (ESRF) requiring hemodialysis compromises immune function.
- Disseminated Herpes Zoster (shingles) is a serious viral reactivation.
Observation:
- A 58-year-old male patient with a history of Darier disease and ESRD on hemodialysis presented with disseminated Herpes Zoster.
- The patient's compromised immune status due to ESRD and dialysis was a significant factor.
Findings:
- Disseminated Herpes Zoster infection was diagnosed.
- Intravenous acyclovir treatment was initiated concurrently with hemodialysis sessions.
- Complete resolution of the Herpes Zoster infection was achieved.
Implications:
- This case highlights the importance of vigilant monitoring for opportunistic infections in immunocompromised patients.
- Concurrent administration of intravenous acyclovir during hemodialysis is a feasible and effective treatment strategy.
- Early recognition and prompt treatment are crucial for managing severe Herpes Zoster in patients with ESRD.
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