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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Early school-age outcomes of late preterm infants
Steven Benjamin Morse1, Hao Zheng, Yiwei Tang
1Department of Pediatrics, University of Florida, Gainesville, FL 32610-0296, USA. morsesb@peds.ufl.edu
Insights
Healthy late preterm infants face increased risks for developmental delays and school problems. These findings highlight the need for closer monitoring of these infants through early school years.
Area of Science:
- Neonatal and Developmental Pediatrics
- Public Health and Epidemiology
Background:
- Late preterm infants (34-36 weeks gestation) are a growing population.
- Historically, they were considered low-risk for long-term morbidities.
- Recent evidence suggests potential developmental challenges.
Purpose of the Study:
- To compare prekindergarten and kindergarten outcomes.
- Focus on healthy late preterm infants versus healthy term infants.
- Investigate long-term morbidities in early school-age years.
Main Methods:
- Large cohort study (N=161804) of singleton births in Florida (1996-1997).
- Included infants born between 34 and 41 weeks gestation with short hospital stays.
- Analyzed seven school-age outcomes, adjusting for 15 maternal and infant variables using Poisson regression.
Main Results:
- Late preterm infants had a 36% higher risk of developmental delay/disability.
- Kindergarten suspension risk was 19% higher.
- Increased risks (10-13%) for prekindergarten disability, special education, and retention were observed.
Conclusions:
- Healthy late preterm infants face significantly greater risks for developmental delays.
- These infants are also at higher risk for school-related issues up to age 5.
- Findings challenge prior assumptions about the minimal risk associated with late preterm birth.
Objective:
Late preterm infants represent a significant portion of preterm deliveries. Until recently, these infants have received little attention because of assumptions that they carry minimal risk for long-term morbidities. The purpose of this study was to compare prekindergarten and kindergarten outcomes among healthy late preterm infants, 34 0/7 to 36 6/7 weeks' gestation at birth, and healthy term infants, 37 0/7 to 41 6/7 weeks' gestation at birth.
Methods:
The study sample consisted of singleton infants who were born in Florida between January 1, 1996, and August 31, 1997, with a gestational age between 34 and 41 weeks (N = 161804) with a length of stay < or =72 hours. Seven early school-age outcomes were analyzed. Outcomes were adjusted for 15 potential confounding maternal and infant variables. Unadjusted and adjusted relative risk with 95% confidence interval was estimated for each outcome by using Poisson regression modeling.
Results:
Risk for developmental delay or disability was 36% higher among late preterm infants compared with term infants. Risk for suspension in kindergarten was 19% higher for late preterm infants. The remaining 4 outcomes, disability in prekindergarten at 3 and 4 years of age, exceptional student education, and retention in kindergarten, all carried a 10% to 13% increased risk among late preterm infants. The assessment "not ready to start school" was borderline significant.
Conclusions:
This study suggests that healthy late preterm infants compared with healthy term infants face a greater risk for developmental delay and school-related problems up through the first 5 years of life.
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