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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine

Désirée Coen Herak1, Margareta Radic Antolic, Jasna Lenicek Krleza

  • 1Clinical Institute of Laboratory Diagnosis, Clinical Hospital Center Zagreb, Zagreb University School of Medicine, Kispaticeva 12, Zagreb 10000, Croatia.

Pediatrics
|April 2, 2009
PubMed

Insights

Inherited prothrombotic factors like Factor V G1691A significantly increase stroke and transient ischemic attack risk in children. Platelet glycoprotein variations may also play a role in migraine and TIA susceptibility.

Area of Science:

  • Pediatric Neurology
  • Hematology
  • Genetics

Background:

  • Childhood stroke, transient ischemic attack (TIA), and migraine are serious neurological conditions.
  • Understanding the role of inherited prothrombotic risk factors is crucial for risk assessment and prevention.

Purpose of the Study:

  • To investigate the prevalence of inherited prothrombotic risk factors in children diagnosed with stroke, TIA, or migraine.
  • To explore the association between specific genetic polymorphisms and these neurological conditions.

Main Methods:

  • Genotypic analysis was performed for Factor V G1691A, Factor II G20210A, MTHFR C677T, and platelet glycoprotein polymorphisms (HPA-1, -2, -3, -5).
  • 150 children with stroke, TIA, or migraine were compared to 112 age-matched controls without thromboembolic history.

Main Results:

  • Factor V G1691A heterozygosity was linked to a sevenfold increased risk of arterial ischemic stroke and TIA.
  • Specific human platelet alloantigen (HPA) alleles (HPA-2b, HPA-5a/b) were associated with increased TIA risk.
  • HPA-2b allele increased migraine risk by 2.23-fold, while HPA-3b showed a protective effect against arterial ischemic stroke.

Conclusions:

  • Factor V G1691A is a significant risk factor for arterial ischemic stroke and TIA in pediatric populations.
  • Platelet glycoprotein polymorphisms may have a minor role in TIA and migraine risk, warranting further investigation in larger cohorts.
Abstract

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