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Updated: Jun 24, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Multiple births are a risk factor for postpartum maternal depressive symptoms
Yoonjoung Choi1, David Bishai, Cynthia S Minkovitz
1Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe St, E8648, Baltimore, MD 21205, USA. ychoi@jhsph.edu
Mothers carrying multiple births face higher risks of postpartum depression. This study found a 43% increased likelihood of moderate to severe depressive symptoms nine months after delivery for mothers of multiples compared to singletons.
Area of Science:
- Reproductive Health
- Maternal Mental Health
- Perinatal Psychiatry
Background:
- Postpartum depression affects a significant number of mothers.
- Maternal mental health is crucial for child development.
- The impact of plurality on postpartum mental health requires further investigation.
Purpose of the Study:
- To examine the association between multiple births and maternal depressive symptoms.
- To assess depressive symptoms at 9 months postpartum.
- To identify potential disparities in maternal mental health based on birth plurality.
Main Methods:
- Utilized data from the Early Childhood Longitudinal Study-Birth Cohort.
- Measured depressive symptoms using the Center for Epidemiologic Studies Depression Scale (CES-D).
- Employed logistic regression analysis, adjusting for key demographic and socioeconomic factors.
Main Results:
- Prevalence of moderate/severe depressive symptoms was 16.0% for singleton mothers and 19.0% for multiple birth mothers.
- Mothers of multiple births had 43% greater odds of experiencing moderate/severe depressive symptoms at 9 months postpartum.
- No significant difference in mental health service utilization for depressive symptoms based on plurality status.
Conclusions:
- Mothers of multiple births are at a significantly higher risk for postpartum depressive symptoms.
- Pediatric settings should increase focus on identifying and supporting maternal depression in families with multiple births.
- Early intervention and targeted support are essential for improving maternal well-being in this population.
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