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Does histologic grade in soft tissue sarcoma influence response rate to systemic chemotherapy?
C M van Haelst-Pisani1, J C Buckner, H M Reiman
1Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905.
Cancer
|December 1, 1991
Summary
Tumor histologic grade influences chemotherapy response in metastatic soft tissue sarcoma (STS). Higher grades (4) showed significantly better doxorubicin response rates than lower grades (2 and 3).
Area of Science:
- Oncology
- Pathology
- Clinical Trials
Background:
- Metastatic soft tissue sarcoma (STS) treatment response can vary.
- The role of tumor histologic grade in predicting chemotherapy response in STS is debated.
Purpose of the Study:
- To evaluate the association between tumor histologic grade and chemosensitivity in patients with metastatic STS receiving doxorubicin-based chemotherapy.
Main Methods:
- Retrospective analysis of 116 patients with metastatic STS from four Mayo Clinic prospective studies (1976-1984).
- Tumor samples were graded using Broders' four-tier system.
- Objective regression rates were compared across different histologic grades.
Main Results:
- Objective regression rates were 55% for Grade 4, 23% for Grade 3, and 19% for Grade 2 STS.
- Statistically significant differences in response rates were observed between Grade 2 vs. Grade 4 (P=0.003) and Grade 3 vs. Grade 4 (P=0.006).
- These findings remained significant after adjusting for histologic type, chemotherapy regimen, performance status, age, and prior treatment.
Conclusions:
- Histologic grade is a significant factor correlating with chemotherapy response probability in metastatic STS.
- Histologic grade should be considered a stratification factor in future clinical studies for metastatic STS.