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Updated: Jun 24, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

[Cellular therapy in autoimmune disease]

K Thümmler1, A Ramming, H Schulze-Koops

  • 1Rheumaeinheit, Medizinische Poliklinik, Klinikum der Universität München, Pettenkoferstrasse 8a, Munich, Germany. katja.thuemmler@med.uni-muenchen.de

Zeitschrift Fur Rheumatologie
|April 2, 2009
PubMed

In addition to natural thymus-derived regulatory T-cells (Tregs), peripherally-induced Tregs are of central importance in immune homeostasis. Homotypic interactions between activated effector T-cells and resting memory T-cells induced the generation of IL-10 and IFNgamma producing Tregs in vitro. This mechanism in Treg development allows new insights into T-cell vaccination, which has been employed in pilot trials of multiple sclerosis and rheumatoid arthritis with promising results.

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