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Related Experiment Video

Updated: Jun 24, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

Hematologic neoplasias and acromegaly.

Flavia Regina P Barbosa¹, Leonardo Vieira Neto, Giovanna Aparecida B Lima

¹Division of Endocrinology, Department of Internal Medicine, Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, Ipanema, Rio de Janeiro, Brazil. frpbarbosa@hotmail.com

|April 2, 2009

Summary

Acromegaly may increase the risk of developing blood cancers like multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM). This study presents two rare cases, highlighting the potential link between growth hormone excess and hematologic neoplasias.

Related Experiment Videos

Last Updated: Jun 24, 2026

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells

Published on: March 10, 2023

Area of Science:

Endocrinology
Hematology
Oncology

Background:

Acromegaly, a condition of excess growth hormone (GH) and insulin-like growth factor-I (IGF-I), is uncommon.
Epidemiological data suggest a potential link between elevated IGF-I levels and increased cancer risk.
Cancers are a significant cause of mortality in acromegaly patients.

Observation:

A 59-year-old woman with acromegaly presented with bone pain, weakness, fatigue, and foamy urine, diagnosed with multiple myeloma (MM).
A 60-year-old woman with acromegaly experienced dizziness, vomiting, abdominal pain, hypertension, and splenomegaly, diagnosed with Waldenstrom's macroglobulinemia (WM).
Both patients had acromegaly, a rare condition characterized by excessive GH and IGF-I.

Findings:

The study describes two rare cases of acromegaly co-occurring with hematologic malignancies (MM and WM).
GH and IGF-I are known to activate B cell lymphocytes, and IGF-I receptors are present on MM cells.
These cases support the debated hypothesis that elevated IGF-I may enhance neoplastic risk.

Implications:

These findings warrant further investigation into the association between acromegaly and hematologic neoplasias.
Understanding this link could lead to improved monitoring and early detection strategies for acromegaly patients.
The study contributes to the ongoing discussion regarding the oncogenic potential of GH/IGF-I signaling pathways.