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Published on: November 5, 2016
Development and in vitro evaluation of floating rosiglitazone maleate microspheres
M R P Rao1, S G Borate, K C Thanki
1AISSMS College of Pharmacy, Kennedy Road, Pune, India. monicarp_6@hotmail.com.
Background:
Various approaches have been used to retain the dosage form in stomach as a way of increasing the gastric residence time, including floatation systems; high-density systems; mucoadhesive systems; magnetic systems; unfoldable, extensible, or swellable systems; and superporous hydrogel systems.
Aim:
The objective of this study was to prepare and evaluate floating microspheres of rosiglitazone maleate for the prolongation of gastric residence time.
Method:
The microspheres were prepared by solvent diffusion-evaporation method using ethyl cellulose and hydroxypropylmethylcellulose. A full factorial design was applied to optimize the formulation.
Results:
Preliminary studies revealed that the polymer:drug ratio, concentration of polymer, and stirring speed significantly affected the characteristics of microspheres. The optimum batch exhibited a prolonged drug release, remained buoyant for >12 hours, high entrapment efficiency, and particle size in the order of 350 microm.
Conclusion:
The results of 32 full factorial design revealed that the concentration of ethylcellulose 7 cps (X(1)) and stirring speed (X(2)) significantly affected drug entrapment efficiency, percentage release after 8 h and particle size of microspheres.
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