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Related Experiment Video

Updated: Jun 24, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

Heterotopic ossification in systemic sclerosis.

V G Botzoris¹, M I Argyropoulou, P V Voulgari

¹Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Scandinavian Journal of Rheumatology

|April 2, 2009

Summary

This study reports a rare case of extensive calcification and ossification in a systemic sclerosis patient, presenting with myopathy and functional impairment. This finding is unique as ossification is not typical in systemic sclerosis.

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Area of Science:

Rheumatology
Orthopedics
Pathology

Background:

Systemic sclerosis (SSc) can present with myopathy and soft tissue calcification.
Ossification is not a recognized feature of systemic sclerosis.

Observation:

An unusual case of extensive calcification and ossification in the gluteal region, thigh, and knee was observed.
The patient experienced associated myopathy and functional impairment.

Findings:

This represents the first reported instance of heterotopic ossification (HO), also known as myositis ossificans, in a patient with scleroderma.
The observed ossification required differential diagnosis from other causes of extraskeletal ossification.

Implications:

This case highlights the potential for rare complications in systemic sclerosis.
It underscores the importance of considering heterotopic ossification in scleroderma patients with extraskeletal calcification and functional decline.
Further research may be needed to understand the mechanisms behind HO in SSc.