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Related Experiment Video

Updated: Jun 24, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis

Published on: March 20, 2026

Microvascular adaptive changes in experimental endogenous brain gliomas.

S Bulnes1, J Bilbao, J V Lafuente

  • 1Laboratory of Clinical and Experimental Neuroscience (LaNCE), Department of Neuroscience, Basque Country University, Leioa, Spain. onbbuses@lg.ehu.es

Histology and Histopathology
|April 2, 2009
PubMed
Summary

Glioma growth alters brain microvasculature, leading to aberrant vessel structures and increased permeability. These adaptive changes impact blood flow and nutrient delivery in high-grade gliomas.

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Last Updated: Jun 24, 2026

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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Area of Science:

  • Neuro-oncology
  • Vascular biology
  • Cancer research

Background:

  • Glioma progression is intrinsically linked to microvascular adaptation and angiogenesis.
  • Understanding structural microvascular changes is crucial for deciphering glioma growth dynamics.

Purpose of the Study:

  • To investigate the structural and functional adaptations of the microvasculature during glioma development.
  • To correlate vascular morphology, permeability, and molecular markers with glioma grade.

Main Methods:

  • Induced rat gliomas were analyzed using magnetic resonance imaging (MRI) and histopathology.
  • Vascular morphology, morphometry, and permeability were assessed, including blood-brain barrier (BBB) integrity via EBA and GluT-1 immunostaining.
  • VEGF165 immunoexpression was evaluated and correlated with vascular permeability.

Main Results:

  • Microtumors (low-grade) showed homogeneous, mildly dilated vessels similar to normal tissue.
  • Macrotumors (high-grade) exhibited aberrant vasculature with decreased vessel density but increased relative vascular area.
  • Tumor cores had scarce, dilated vessels (GluT-1/VEGF165+), while borders showed glomeruloid vessels (VEGF+); BBB disruption correlated with glucose uptake.

Conclusions:

  • Glioma development induces aberrant microvascular changes, including altered distribution and permeability.
  • These adaptive vascular modifications contribute to disturbed blood flow and increased permeability observed in gliomas.
  • The findings highlight the dynamic nature of the tumor microvasculature in response to glioma growth.