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Related Experiment Video

Updated: Jun 24, 2026

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

BMP6 orchestrates iron metabolism.

Clara Camaschella¹

¹Università Vita-Salute & Istituto Scientifico San Raffaele, Division of Genetics and Cell Biology, Milano, Italy. camaschella.clara@hsr.it

Nature Genetics

|April 2, 2009

Summary

The liver peptide hepcidin regulates iron levels in the body. New research reveals Bone Morphogenetic Protein 6 (BMP6) as the primary natural signal controlling hepcidin.

Area of Science:

Physiology
Molecular Biology
Endocrinology

Background:

Hepcidin, a small liver peptide, is crucial for maintaining systemic iron homeostasis in mammals.
Iron absorption is dynamically regulated by hepcidin in response to the body's iron requirements.

Discussion:

Two recent studies pinpoint Bone Morphogenetic Protein 6 (BMP6) as the principal endogenous factor influencing hepcidin production.
This discovery clarifies a critical regulatory pathway in iron metabolism.

Key Insights:

BMP6 is identified as the key natural regulator of hepcidin.
Understanding this BMP6-hepcidin axis is vital for comprehending iron balance.

Outlook:

Further research into the BMP6-hepcidin pathway could lead to new therapeutic strategies for iron-related disorders.

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Investigating downstream signaling of BMP6 will enhance our knowledge of iron regulation.