Genetics of cardiac repolarization
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Updated: Jun 24, 2026

Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection
Published on: February 17, 2015
Svati H Shah1, Geoffrey S Pitt
1Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA. svati.shah@duke.edu
Abstract:
Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, is associated with arrhythmogenic disorders and is a risk factor for sudden cardiac death. Two genome-wide association studies (GWAS) of variation in the QT interval in population-based cohorts now report association with variants in a subset of ion channel genes and other new associations.
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