18O2-labeling in quantitative proteomic strategies: a status report

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Protease- and Acid-catalyzed Labeling Workflows Employing 18O-enriched Water
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Protease- and Acid-catalyzed Labeling Workflows Employing 18O-enriched Water

Published on: February 20, 2013

Catherine Fenselau1, Xudong Yao

  • 1Department of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, USA. fenselau@umd.edu

Journal of Proteome Research
|April 3, 2009
PubMed

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...