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Updated: Jun 24, 2026
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Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
Tissue engineering therapies for the vocal fold lamina propria
1MicroEnvironmental Engineering Laboratory, Department of Bioengineering, Clemson University, Clemson, South Carolina 29634, USA.
Tissue Engineering. Part B, Reviews
|April 3, 2009
Summary
Vocal fold tissue engineering aims to restore voice production by developing injectable biomaterials and regenerative therapies to reverse scarring and improve tissue biomechanics after injury.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Laryngeal Physiology
Background:
- Vocal folds are complex connective tissues crucial for voice production.
- Injury to vocal folds alters tissue structure, biomechanics, and voice quality.
- Understanding injury-induced biochemical changes is key to developing effective therapies.
Purpose of the Study:
- To review recent advancements in vocal fold tissue engineering for treating injury-induced scarring.
- To highlight the development of novel biomaterials and regenerative strategies.
- To assess progress toward clinical applications for voice restoration.
Main Methods:
- Development of injectable biomaterial scaffolds with controlled properties.
- Application of cell transplantation and growth factor delivery (e.g., hepatocyte growth factor).
- Utilizing in vitro dynamic culture systems to mimic the vocal fold microenvironment.
Main Results:
- Significant reductions in fibrosis observed in animal models.
- Improved recovery of native tissue viscoelasticity and mechanical function.
- Enhanced vibratory and functional performance in engineered vocal fold tissues.
Conclusions:
- Vocal fold tissue engineering shows promise for clinical application in voice restoration.
- Regenerative therapies are advancing toward reversing vocal fold scarring and dysfunction.
- Biomaterial scaffolds and targeted delivery systems are critical for successful tissue regeneration.
