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Published on: January 14, 2014
Angiocentric glioma: a case series
Sophia F Shakur1, Matthew J McGirt, Michael W Johnson
1Departments of Neurosurgery John Hopkins University School of Medicine, Baltimore, Maryland, USA.
Journal of Neurosurgery. Pediatrics
|April 3, 2009
Summary
Pediatric angiocentric glioma, a rare brain tumor, often presents with seizures. Complete surgical removal of these temporal lobe tumors leads to excellent outcomes and seizure freedom in young patients.
Area of Science:
- Neuro-oncology
- Pediatric Neurology
- Brain Tumor Classification
Background:
- Angiocentric glioma is a distinct clinicopathological entity recognized in the 2007 WHO Classification.
- This study presents the first 3 pediatric cases from the authors' institution.
Purpose of the Study:
- To describe the characteristics and outcomes of pediatric angiocentric glioma.
- To review the literature for reported pediatric cases.
Main Methods:
- Case series of 3 pediatric patients (ages 10-13) with angiocentric glioma.
- Literature review of 22 additional pediatric cases, totaling 25 cases.
- Analysis of clinical presentation, neuroimaging (MRI), histology, and treatment outcomes.
Main Results:
- Common presentation: intractable seizures. One case presented with headache and vision loss.
- MRI findings: superficial, nonenhancing, T2-hyperintense temporal lobe lesions.
- Histology: monomorphic cells with perivascular orientation, glial markers positive.
- All 3 patients achieved gross-total resection and remained seizure-free post-surgery.
Conclusions:
- Seizures are the most frequent symptom of pediatric angiocentric glioma.
- Characteristic MRI findings include supratentorial, nonenhancing lesions.
- Gross-total resection is associated with excellent patient outcomes.
