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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...

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Related Experiment Video

Updated: Jun 24, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
05:54

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

Published on: November 29, 2024

Topical scar modification: hype or help?

Mary H McGrath, David S Chang

    Aesthetic Surgery Journal
    |April 3, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Silicone gel sheeting is the only topical treatment proven effective for hypertrophic scars. Many other scar treatments lack evidence of efficacy, despite common use in plastic surgery.

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    Last Updated: Jun 24, 2026

    A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
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    Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
    07:40

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    In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
    08:20

    In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

    Published on: May 1, 2020

    Area of Science:

    • Plastic Surgery
    • Dermatology
    • Wound Healing

    Background:

    • Topical scar treatments are widely used.
    • Evidence supporting the efficacy of many treatments is lacking.
    • Hypertrophic scars represent a significant clinical challenge.

    Purpose of the Study:

    • To review available topical scar treatments.
    • To discuss the evidence supporting their efficacy.
    • To define the role of these treatments in plastic surgery.

    Main Methods:

    • Literature review of topical scar treatments.
    • Analysis of clinical evidence for efficacy.
    • Discussion of current plastic surgery practices.

    Main Results:

    • Silicone gel sheeting is the only topical treatment with proven efficacy for hypertrophic scars.
    • Many other commonly used topical scar treatments lack robust scientific evidence.
    • The clinical application of various scar treatments is often not evidence-based.

    Conclusions:

    • Silicone gel sheeting should be considered a primary treatment for hypertrophic scars.
    • Clinicians should critically evaluate the evidence for other topical scar treatments.
    • Further research is needed to establish the efficacy of non-silicone topical scar treatments.