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Truncal polyradiculopathy due to sarcoidosis
Akiyuki Uzawa1, Shigeyuki Kojima, Tadahiro Yonezu
1Department of Neurology, Matsudo Municipal Hospital, Chiba, Japan. a-uzimp1204@umin.ac.jp
Journal of the Neurological Sciences
|April 3, 2009
Summary
Neurosarcoidosis can affect cranial nerves and cause trunk polyradiculopathy. This rare condition in a 43-year-old woman improved with steroid treatment.
Area of Science:
- Neurology
- Immunology
Background:
- Neurosarcoidosis is a rare multisystem inflammatory disease affecting the nervous system.
- Cranial nerve involvement is a common manifestation of neurosarcoidosis.
Observation:
- A 43-year-old woman presented with multiple cranial nerve palsies including visual loss, facial weakness, and dysphagia.
- Clinical findings included hilar lymphadenopathy, uveitis, and elevated serum angiotensin-converting enzyme (ACE) levels.
- She also experienced truncal hypoesthesia and bilateral arm sensory disturbances.
Findings:
- Diagnosis of neurosarcoidosis was confirmed by clinical features and exclusion of tuberculosis.
- Cerebrospinal fluid analysis revealed elevated cell count and protein.
- Nerve conduction studies indicated polyradiculopathy affecting the trunk and ulnar nerves.
- Magnetic resonance imaging of the spine showed normal findings.
Implications:
- This case highlights truncal polyradiculopathy as a rare but significant neurological finding in neurosarcoidosis.
- Early diagnosis and steroid therapy can lead to symptom improvement.
- Understanding these diverse neurological manifestations is crucial for effective patient management.
