Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histologic prognostic factors in ependymoma.

D Schiffer1, A Chiò, M T Giordana

  • 1Second Department of Neurology, University of Turin, Italy.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|August 1, 1991
PubMed
Summary

Histologic factors like mitosis count significantly impact ependymoma prognosis, especially in supratentorial tumors. Age and tumor site are also crucial for predicting outcomes in these brain tumors.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular immune signature identifies microglia and NK cell infiltration as a favorable prognostic marker in adult-type high-grade glioma.

ESMO open·2026
Same author

A case of seropositive autoimmune autonomic ganglionopathy treated with rituximab: Case report and review of the literature.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

A novel DHTKD1 variant is associated with an atypical form of Charcot-Marie-Tooth disease type 2Q?

Acta neurologica Belgica·2023
Same author

Presymptomatic geographical distribution of ALS patients suggests the involvement of environmental factors in the disease pathogenesis.

Journal of neurology·2023
Same author

Long term follow up in 183 high grade meningioma: A single institutional experience.

Clinical neurology and neurosurgery·2021
Same author

Plateaus in amyotrophic lateral sclerosis progression: results from a population-based cohort.

European journal of neurology·2020

Area of Science:

  • Neuro-oncology
  • Pathology

Background:

  • Ependymomas are primary brain tumors arising from ependymal cells.
  • Accurate prognostic indicators are essential for guiding treatment and predicting outcomes in ependymoma patients.

Purpose of the Study:

  • To investigate the prognostic value of various histologic signs and clinical features in a large cohort of ependymomas.
  • To identify key factors influencing survival across different tumor locations and age groups.

Main Methods:

  • Retrospective analysis of 298 ependymomas from multiple institutions.
  • Univariate and multivariate statistical analyses, including life table and Cox regression models.
  • Evaluation of histologic features (mitoses, endothelial hyperplasia, necrosis) and clinical data (age, tumor site).

Related Experiment Videos

Main Results:

  • Significant prognostic factors identified by univariate analysis include mitotic count, endothelial hyperplasia, necrosis, intracranial site, and age under 4 years.
  • Multivariate analysis highlighted mitoses cell density, age over 16 years (supratentorial), and subependymoma (infratentorial) as important.
  • The anaplastic variant did not show a significantly worse survival than other types in intracranial cases, despite a shorter median survival.

Conclusions:

  • Histologic criteria, particularly mitotic count, are critical for ependymoma prognosis, especially in supratentorial tumors.
  • Age and tumor location are significant determinants of ependymoma outcome.
  • Endothelial hyperplasia and necrosis appear less critical as prognostic factors in ependymomas compared to other gliomas.