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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

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Updated: Jun 24, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Medication adherence in healthy elders: small cognitive changes make a big difference.

Tamara L Hayes1, Nicole Larimer, Andre Adami

  • 1Division of Biomedical Engineering, Oregon Health & Sciences University, 3303 SW Bond Avenue, Portland, OR 97239, USA. hayesta@ohsu.edu

Journal of Aging and Health
|April 3, 2009
PubMed
Summary
This summary is machine-generated.

Healthy elders with lower cognitive function demonstrated significantly poorer medication adherence compared to those with high cognitive function. This highlights the impact of even mild cognitive impairment on medication management in older adults.

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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Related Experiment Videos

Last Updated: Jun 24, 2026

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Area of Science:

  • Gerontology
  • Neuroscience
  • Clinical Pharmacy

Background:

  • Medication adherence is crucial for effective treatment in elderly populations.
  • Cognitive function can influence an individual's ability to manage medication regimens.
  • Understanding factors affecting adherence in healthy elders is vital for clinical practice and research.

Purpose of the Study:

  • To assess the relationship between cognitive function and medication adherence in independently living elderly individuals.
  • To compare medication adherence rates between healthy elders with high cognitive function (HCF) and low cognitive function (LCF).

Main Methods:

  • A cross-sectional study involving 38 community-dwelling elders aged 65+.
  • Participants followed a 5-week twice-daily vitamin C regimen.
  • Medication adherence was monitored using an electronic pillbox and categorized based on ADAS-Cog scores.

Main Results:

  • The LCF group exhibited significantly lower total adherence (63.9%) compared to the HCF group (86.8%).
  • The relative risk of non-adherence was 4.1 times higher in the LCF group compared to the HCF group.
  • Statistical analysis showed a significant difference in adherence between the two cognitive groups (p = .007).

Conclusions:

  • Mild cognitive impairment in healthy elderly individuals significantly impairs medication adherence.
  • These findings have critical implications for the design and interpretation of clinical drug trials involving older adults.
  • Interventions to support medication adherence may be necessary for elderly individuals with even subtle cognitive deficits.