Related Experiment Video
Updated: Jun 24, 2026
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
A retrospective analysis of thirty-one cases of plasma cell leukemia from a single center in China
Qi Peijing1, Xu Yan, Wang Yafei
1Blood Disease Hospital and Institute of Hematology, Chinese Academy of Medical Science, Tianjin, China.
Background/Aims:
The study was undertaken to understand the characteristic of plasma cell leukemia (PCL) in China.
Methods:
We reviewed and compared medical data of 22 primary PCL, 9 secondary PCL and 461 multiple myeloma (MM) diagnosed at our institute from January 2000 to January 2008.
Results:
The median onset ages of primary and secondary PCL patients were 49.5 and 56 years, respectively. PCL patients presented with a low peripheral blood plasmacytosis, extensive involvement of visceral organs and poor residual bone marrow function, without severe renal insufficiency. Seventeen of twenty-one PCL patients had abnormal karyotypes, mostly complex and hypodiploid or pseudodiploid. The deletion of 13q was frequent in primary and secondary PCL (57.1 and 42.9%, respectively). There was a significant difference in survival among primary PCL, secondary PCL and MM (median 14, 2 and 37 months, respectively, p = 0.0000).
Conclusion:
Overall, primary and secondary PCL are different disorders with distinct natural histories and survival.
