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Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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Renal Corpuscle01:20

Renal Corpuscle

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
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Renal Clearance01:23

Renal Clearance

2.7K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
2.7K
Renal Drug Clearance: Comparison Between Renal Excretion Methods01:08

Renal Drug Clearance: Comparison Between Renal Excretion Methods

620
Renal clearance is a critical parameter encompassing kidney filtration, secretion, and reabsorption processes. It is calculated using a specific equation to determine the rate at which the kidneys clear a drug.
Renal clearance is often associated with the renal glomerular filtration rate (GFR), which represents the rate at which plasma is filtered through the glomeruli in the kidney. When drug reabsorption is minimal and there is no active secretion, renal clearance is closely related to the...
620
Drug Elimination: Non-Renal Routes01:23

Drug Elimination: Non-Renal Routes

3.3K
The liver plays a pivotal role in eliminating drugs and their metabolites, primarily through a process known as biliary excretion. This process involves the hepatocytes, the primary cells in the liver that generate bile. A range of transporters actively expels polar drugs or hydrophilic drug metabolites into the bile, which transports the drugs and metabolites into the small intestine. From here, they are eventually expelled from the body through feces. In some instances, the original drug or a...
3.3K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

3.6K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.6K

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Related Experiment Video

Updated: Feb 10, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Renal cell carcinoma.

Jorge A Garcia1, C Lance Cowey, Paul A Godley

  • 1Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, Ohio, USA.

Current Opinion in Oncology
|April 3, 2009
PubMed
Summary

Recent advancements in renal cell carcinoma (RCC) treatment offer new hope. This review covers evolving therapies, biomarkers, and management strategies for advanced RCC.

Area of Science:

  • Oncology
  • Urology

Background:

  • Renal cell carcinoma (RCC) is a significant health concern.
  • Current treatment landscapes are rapidly evolving.

Purpose of the Study:

  • To review recent advancements in renal cell carcinoma (RCC) treatments.
  • To provide insights into clinical and molecularly based biomarker studies for RCC.

Main Methods:

  • Comprehensive literature review of recent studies on RCC.
  • Analysis of epidemiological data and clinical prognostic factors.
  • Evaluation of molecularly based biomarker studies and therapeutic agents.

Main Results:

  • Updates on front-line therapy for RCC are presented.
  • Early clinical evidence on sequential or combination targeted agents is discussed.

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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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  • Recent findings in RCC epidemiology and prognostic factors are detailed.

    • Conclusions:

    • The treatment paradigm for advanced RCC is continuously evolving.
    • Novel therapeutic agents are on the horizon for RCC management.
    • This review provides an update on epidemiology, biomarker development, and management of advanced RCC.