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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

HIV-associated Hodgkin lymphoma.

Antonino Carbone¹, Annunziata Gloghini, Diego Serraino

¹Department of Pathology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy. antonino.carbone@istitutotumori.mi.it

Current Opinion in HIV and AIDS

|April 3, 2009

Summary

People with HIV are at increased risk of Hodgkin lymphoma, even with effective treatment. This review covers the epidemiology, pathology, and treatment of HIV-associated Hodgkin lymphoma (HIV-HL).

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Last Updated: Jun 24, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Area of Science:

Oncology
Infectious Diseases
Immunology

Background:

An increased risk of Hodgkin lymphoma (HL) has been observed among non-AIDS-defining cancers.
The precise relationship between human immunodeficiency virus (HIV) infection, acquired immunodeficiency syndrome (AIDS), and HL remains incompletely understood.

Purpose of the Study:

To review current knowledge on the epidemiology, pathology, and treatment of HIV-associated Hodgkin lymphoma (HIV-HL).

Main Methods:

Literature review of studies on HIV-HL.
Analysis of epidemiological data, pathological features, and treatment outcomes.
Examination of the role of Epstein-Barr virus (EBV) and immune status in HIV-HL pathogenesis.

Main Results:

HIV-infected individuals face an elevated risk of HL in the highly active antiretroviral therapy (HAART) era.
Tumor characteristics and subtype distribution in HIV-HL differ significantly from HIV-uninfected HL.
Epstein-Barr virus (EBV) latent membrane protein 1 expression in nearly all HIV-HL cases suggests a key etiological role.

Conclusions:

HIV-HL presents unique pathological features, potentially influenced by improved immunity and EBV.
Advances in combined therapies offer promising treatment strategies for HIV-HL.
Continued research is crucial for understanding and managing HIV-HL effectively.