Imaging Biological Samples with Optical Microscopy
Difference from Background: Limit of Detection
You might also read
Articles linked to this work by shared authors, journal, and citation graph.
Updated: Jun 24, 2026

Pupillometry to Assess Auditory Sensation in Guinea Pigs
Published on: January 6, 2023
Saeed Bagheri1, Paulo E X Silveira, George Barbastathis
1IBM T. J. Watson Research Center, 1101 Kitchawan Road, Room 11-209, Yorktown Heights, New York 10598, USA. sbagher@us.ibm.com
We found a fundamental limit to extending depth-of-field (DOF) in imaging systems. This limit involves a tradeoff between DOF extension and spectral signal-to-noise ratio (SNR), introducing a spectral SNR conservation principle.
Area of Science:
Background:
Purpose of the Study:
Main Methods:
Main Results:
Conclusions: