Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Cross-reactivity

Cross-reactivity

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Colonisation of Pathogens

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation.

Mucosal immunology·2015

Same author

Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's disease?

European journal of microbiology & immunology·2014

Same author

Second-trimester diagnosis of triploidy: a series of four cases.

AJP reports·2013

Same author

Pregnancy in an individual with mild Smith-Lemli-Opitz syndrome.

Clinical genetics·2013

Same author

TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior.

Oncogene·2012

Same author

Molecular detection of multiple endocrine neoplasia type 2.

Methods in molecular medicine·2011

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

Microfluidic Co-culture of Epithelial Cells and Bacteria for Investigating Soluble Signal-mediated Interactions

Microfluidic Co-culture of Epithelial Cells and Bacteria for Investigating Soluble Signal-mediated Interactions

Published on: April 20, 2010

Molecular cross talk between epithelial cells and pathogenic microorganisms.

M J Wick¹, J L Madara, B N Fields

¹Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110.

|November 15, 1991

Summary

Epithelial cell biology and molecular microbiology are interconnected. Novel approaches are advancing our understanding of microbial-epithelial interactions, crucial for developing new antimicrobial agents and studying disease.

More Related Videos

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

Published on: January 6, 2014

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

Related Experiment Videos

Last Updated: Jul 18, 2026

Microfluidic Co-culture of Epithelial Cells and Bacteria for Investigating Soluble Signal-mediated Interactions

Microfluidic Co-culture of Epithelial Cells and Bacteria for Investigating Soluble Signal-mediated Interactions

Published on: April 20, 2010

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

Published on: January 6, 2014

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Analysis of the Epithelial Damage Produced by Entamoeba histolytica Infection

Published on: June 12, 2014

Area of Science:

Microbiology
Cell Biology
Immunology

Background:

Diverse scientific disciplines, including epithelial cell biology and molecular microbiology, are intricately linked.
Understanding the microbial-epithelial interface is key to addressing critical biological questions.

Framework:

Novel model systems and advanced techniques are essential for dissecting molecular mechanisms at the microbial-epithelial interface.
Co-crystallization of ligand-receptor complexes aids in determining interaction details.
Transfection techniques, animal models, and transgenic mice facilitate the study of host-microbe interactions.

Implementation:

Focus on novel approaches to understand molecular details of responses at the microbial-epithelial interface.
Utilizing co-crystallization to determine receptor-ligand interactions.
Employing transfection, animal models, and transgenic mice for dissecting microbial-epithelial interactions.

Implications:

Advances in understanding microbial-epithelial interactions are critical for developing next-generation antimicrobial agents.
Further research will enhance studies on pathogenesis, tissue tropism, and host tropism.
Cross-disciplinary collaboration is vital for unraveling microbe-host communication and its relation to disease and immune function.