Related Experiment Video
Updated: Jun 24, 2026

Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
Published on: December 23, 2010
The putative role of leukotrienes in experimental atherogenesis
1Department of Pharmacology, Jagiellonian University, Medical College, Kraków, Poland. mmjawien@cyf-kr.edu.pl
Abstract:
Since inflammation plays an important role in atherogenesis, during recent years it has become apparent that the 5-lipoxygenase (5-LO) pathway may take a significant part in the pathogenesis of atherosclerosis. These data raised the possibility that antileukotriene drugs may be an effective treatment regimen in atherosclerosis. This review describes the research performed on the apolipoprotein E/low-density lipoprotein receptor-double knockout mice as a model of atherosclerosis. The study has shown that 5-LO activating protein inhibitors and leukotriene receptor blockers decrease atherosclerosis in atherosclerotic mice. The article also discusses the importance of these findings for the future use in the clinic.
Related Concept Videos
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
Atherosclerosis I: Introduction
Inflammation
Coronary Artery Disease II: Pathophysiology
Acute Inflammation III: Local and Systemic Effects
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
