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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
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Published on: January 26, 2024

Functional changes of human peripheral B-lymphocytes in pre-eclampsia.

Ai-Hua Liao1, Li-Ping Liu, Wen-Ping Ding

  • 1Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. aihualiao@hotmail.com

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|April 4, 2009
PubMed
Summary

Functional changes in circulating B-cells, specifically increased memory B-cells and plasma cell precursors, were observed in pre-eclamptic pregnancies. These alterations in B-lymphocytes may play a role in the development of pre-eclampsia.

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Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

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Published on: May 21, 2015

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Last Updated: Jun 24, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

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Published on: January 26, 2024

Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Area of Science:

  • Immunology
  • Obstetrics
  • Perinatal Medicine

Background:

  • Pre-eclampsia is a serious pregnancy complication characterized by high blood pressure.
  • B-lymphocytes play a crucial role in the immune response and antibody production.
  • Understanding B-cell function in pre-eclampsia is vital for identifying potential therapeutic targets.

Purpose of the Study:

  • To investigate the functional differences of peripheral B-lymphocytes in women with pre-eclampsia compared to healthy pregnant women.
  • To analyze specific B-cell subsets and their antibody-producing capacity.

Main Methods:

  • Peripheral blood mononuclear cells (PBMCs) were isolated from 20 pre-eclamptic and 15 healthy pregnant women.
  • B-cell subsets were analyzed using flow cytometry with anti-CD27 and anti-CD38 antibodies.
  • Plasma cell morphology and antibody production were assessed after in vitro stimulation with pokeweed mitogen (PWM).

Main Results:

  • Pre-eclamptic women showed increased percentages of CD27(+)CD38(-) memory B-cells and CD27(+)CD38(+) plasma cell precursors.
  • Significantly higher percentages of generated plasma cells were observed in pre-eclamptic women, both with and without PWM stimulation.
  • Elevated antibody-producing cells were detected in pre-eclamptic women post-PWM activation.

Conclusions:

  • Functional alterations in circulating B-cells, including enhanced memory B-cell and plasma cell precursor populations, are associated with pre-eclampsia.
  • These B-cell changes may contribute to the underlying pathophysiology of pre-eclampsia.
  • Further research into B-cell modulation could offer new avenues for managing pre-eclampsia.