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Related Experiment Video

Updated: Jun 24, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Smoking and oral contraceptive continuation.

Carolyn Westhoff¹, Kandice Jones, Christina Robilotto

¹Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. clw3@columbia.edu

|April 4, 2009

Summary

Young women who smoke are more likely to stop taking oral contraceptives (OC) early. Smoking may indicate risk-taking behaviors leading to early OC discontinuation.

Related Experiment Videos

Last Updated: Jun 24, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System

Published on: October 22, 2020

Area of Science:

Reproductive Health
Behavioral Science

Background:

Smoking is a prevalent behavior among young women.
Oral contraceptives (OC) are widely used for birth control and managing gynecologic conditions.
Previous research suggests a potential link between smoking and OC use, but data on early discontinuation are limited.

Purpose of the Study:

To investigate the association between smoking status and early discontinuation of oral contraceptives (OC) in young women.
To determine if smoking is a predictor of premature OC cessation.

Main Methods:

Secondary analysis of a randomized clinical trial involving women under 25 initiating OC.
Smoking status assessed at enrollment; OC continuation evaluated at 3- and 6-month interviews.
Statistical analysis, including adjusted odds ratios, to assess the relationship between smoking and OC continuation.

Main Results:

12% of 1598 participants were current smokers.
Smokers had higher rates of loss to follow-up (P<.01).
At 6 months, 26% of smokers continued OC versus 46% of nonsmokers (P<.001). Adjusted OR 0.6 (95% CI 0.4-1.0).

Conclusions:

Young female smokers are significantly more likely to discontinue oral contraceptives within 6 months.
Smoking may serve as a marker for broader risk-taking behaviors, including premature OC discontinuation.
Interventions addressing smoking cessation could potentially improve OC adherence in young women.