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Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 24, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Chemotherapy-induced alopecia.

Ralph M Trüeb1

  • 1Department of Dermatology, University Hospital of Zurich, Gloriastr 31, CH-8091, Zurich, Switzerland. ralph.trueeb@usz.ch

Seminars in Cutaneous Medicine and Surgery
|April 4, 2009
PubMed
Summary
This summary is machine-generated.

Chemotherapy-induced alopecia (CIA) causes significant distress. Understanding CIA

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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Last Updated: Jun 24, 2026

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
04:48

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

Published on: January 7, 2015

Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Chemotherapy-induced alopecia (CIA) is a distressing dermatologic condition with variable incidence and severity.
  • Understanding the pathobiology of CIA is crucial for developing effective prevention strategies.
  • Current approaches like scalp cooling have limitations due to poor data quality.

Purpose of the Study:

  • To review the pathobiology of chemotherapy-induced alopecia.
  • To explore current and experimental strategies for preventing or mitigating CIA.
  • To highlight the need for follicle-selective protective agents.

Main Methods:

  • Review of existing literature on chemotherapy-induced alopecia.
  • Analysis of pathobiology, clinical patterns, and influencing factors of CIA.
  • Evaluation of current interventions (scalp cooling) and experimental pharmacologic agents.

Main Results:

  • CIA presents with diverse clinical patterns beyond simple anagen effluvium.
  • Scalp cooling is a primary method but lacks robust supporting data.
  • Experimental agents targeting hair growth cycles, apoptosis, and proliferation are under investigation.
  • AS101 and minoxidil showed partial efficacy in reducing CIA severity or duration but not prevention.

Conclusions:

  • Effective prevention of chemotherapy-induced alopecia requires a deeper understanding of its complex pathobiology.
  • Future strategies should focus on selective hair follicle protection without compromising chemotherapy efficacy.
  • Further research into novel pharmacologic agents and optimized scalp cooling is warranted.