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Study on cholesteryl ester transfer activity in coronary heart disease
Y Fujinuma1, A Tanaka, H Maezawa
1Third Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University.
Insights
Cholesterol transfer activity (CETA) from HDL to LDL is elevated in coronary heart disease (CHD) patients with low HDL cholesterol, suggesting a risk factor. In contrast, high HDL cholesterol in CHD patients is linked to larger HDL particle size, also indicating potential risk.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Coronary heart disease (CHD) pathogenesis is complex, involving lipid metabolism.
- High-density lipoprotein (HDL) cholesterol levels and cholesterol transfer activity are implicated in atherosclerosis.
- Understanding the role of cholesterol transfer activity and HDL particle size in CHD is crucial.
Purpose of the Study:
- To investigate the net cholesterol transfer activity from HDL to LDL in CHD patients.
- To examine the relationship between cholesterol transfer activity, HDL cholesterol levels, and arteriosclerosis.
- To analyze HDL particle size in CHD patients with high HDL cholesterolemia.
Main Methods:
- Measurement of net cholesterol transfer activity between HDL and LDL.
- Determination of serum HDL cholesterol levels.
- High-performance liquid chromatography (HPLC) for HDL particle size analysis.
Main Results:
- Significant elevation in cholesteryl ester transfer activity (CETA) was observed in CHD patients with low HDL cholesterolemia (<60 mg/dl).
- A negative correlation was found between CETA rate and serum HDL cholesterol values in CHD patients.
- CHD patients with high HDL cholesterolemia (>60 mg/dl) did not show increased CETA, but exhibited significantly larger HDL particle size compared to normal subjects.
Conclusions:
- Increased CETA may contribute to low HDL cholesterol levels, posing a risk for CHD.
- Elevated CETA is associated with low HDL cholesterol in CHD patients.
- Large HDL particle size in CHD patients with high HDL cholesterolemia may also represent a risk factor for CHD.
Abstract:
The net cholesterol transfer activity from high density lipoprotein (HDL) to low density lipoprotein (LDL) was determined in the patients with coronary heart disease (CHD) to examine its effect on the pathogenesis of arteriosclerosis. Furthermore, in the CHD patients with high HDL cholesterolemia (more than 60 mg/dl), the HDL particle size was measured by high performance liquid chromatography. A significant cholesteryl ester transfer activity (P less than 0.02) was noted in the CHD patients with low HDL cholesterolemia (less than 60 mg/dl). The rate of cholesteryl ester transfer activity (cholesteryl ester transfer activity/hour) inversely correlated with the serum HDL cholesterol value (r = -0.483, P = 0.096) in the patients with CHD. These results suggest that an increase of CETA caused a low HDL cholesterol value in the CHD patients with low HDL cholesterolemia and it may have the risk of causing CHD. However, an increase of the CETA was not found in the CHD patients with high HDL cholesterolemia compared to the normal subjects, the HDL particle size being significantly greater than that in the normal subjects. In the CHD patients with high HDL cholesterolemia, the large size of HDL may have the risk of causing CHD.