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Study on cholesteryl ester transfer activity in coronary heart disease
Y Fujinuma1, A Tanaka, H Maezawa
1Third Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University.
The Bulletin of Tokyo Medical and Dental University
|September 1, 1991
Summary
Cholesterol transfer activity (CETA) from HDL to LDL is elevated in coronary heart disease (CHD) patients with low HDL cholesterol, suggesting a risk factor. In contrast, high HDL cholesterol in CHD patients is linked to larger HDL particle size, also indicating potential risk.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Coronary heart disease (CHD) pathogenesis is complex, involving lipid metabolism.
- High-density lipoprotein (HDL) cholesterol levels and cholesterol transfer activity are implicated in atherosclerosis.
- Understanding the role of cholesterol transfer activity and HDL particle size in CHD is crucial.
Purpose of the Study:
- To investigate the net cholesterol transfer activity from HDL to LDL in CHD patients.
- To examine the relationship between cholesterol transfer activity, HDL cholesterol levels, and arteriosclerosis.
- To analyze HDL particle size in CHD patients with high HDL cholesterolemia.
Main Methods:
- Measurement of net cholesterol transfer activity between HDL and LDL.
- Determination of serum HDL cholesterol levels.
- High-performance liquid chromatography (HPLC) for HDL particle size analysis.
Main Results:
- Significant elevation in cholesteryl ester transfer activity (CETA) was observed in CHD patients with low HDL cholesterolemia (<60 mg/dl).
- A negative correlation was found between CETA rate and serum HDL cholesterol values in CHD patients.
- CHD patients with high HDL cholesterolemia (>60 mg/dl) did not show increased CETA, but exhibited significantly larger HDL particle size compared to normal subjects.
Conclusions:
- Increased CETA may contribute to low HDL cholesterol levels, posing a risk for CHD.
- Elevated CETA is associated with low HDL cholesterol in CHD patients.
- Large HDL particle size in CHD patients with high HDL cholesterolemia may also represent a risk factor for CHD.