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Stress echocardiography for the risk stratification of patients following coronary bypass surgery
Lauro Cortigiani1, Riccardo Bigi, Rosa Sicari
1Division of Cardiology, Campo di Marte Hospital, Lucca, Italy.
Insights
Stress echocardiography (SE) effectively predicts cardiac events in patients post-coronary artery bypass grafting (CABG). This non-invasive test aids risk stratification for both symptomatic and asymptomatic individuals.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Preventive Medicine
Background:
- Coronary artery bypass grafting (CABG) is a common revascularization procedure.
- Long-term prognosis after CABG requires effective risk stratification tools.
- Stress echocardiography (SE) assesses myocardial viability and function.
Purpose of the Study:
- To evaluate the prognostic capability of stress echocardiography (SE) in patients who have undergone surgical revascularization.
- To determine if SE can predict adverse cardiac events after CABG.
- To assess the utility of SE in both symptomatic and asymptomatic post-CABG patients.
Main Methods:
- A cohort of 500 patients (100 women) with prior CABG underwent exercise or pharmacological SE.
- Patients were assessed a median of 69 months post-CABG.
- Follow-up was conducted for a median of 25 months to record hard events (mortality, myocardial infarction) and late revascularization.
Main Results:
- Stress echocardiography (SE) indicated ischemia in 39% of patients.
- Age and peak Wall Motion Score Index (WMSI) were independent predictors of hard events.
- SE significantly improved the predictive power of risk models, identifying higher event rates in patients with ischemia.
Conclusions:
- Stress echocardiography (SE) is a valuable tool for risk stratification in patients with a history of CABG.
- SE provides prognostic information regardless of the presence or absence of ischemic symptoms.
- SE aids in identifying patients at higher risk for adverse cardiac events post-CABG.
Objectives:
The aim of the study was to assess the prognostic value of stress echocardiography after surgical revascularization.
Methods:
We evaluated 500 (100 women) patients who had undergone exercise or pharmacological SE after a median of 69 months after coronary artery by-pass grafting (CABG). Of these, 351 (70%) complained of symptoms suggestive of ischemic origin while 149 (30%) were tested for asymptomatic progression of the disease.
Results:
SE was positive for ischemia in 196 (39%) patients. During a median follow-up of 25 months, 61 patients died, 33 had a nonfatal myocardial infarction, and 112 underwent late (>3 months) revascularization. Multivariable Cox' regression analysis indicated age (HR=1.04; 95% CI 1.01-1.06; p<0.003), and peak WMSI (HR=3.07; 95% CI 1.96-4.81; p=0.0001) as independent predictors of hard (total mortality and myocardial infarction) events. SE information provided a significant improvement in predictive power of the statistical model (chi-square increase 34%, p<0.0001 for hard and 91%, p<0.0001 for major events, respectively). Survival analysis showed ischemia at SE to be associated with significantly higher hard and major event rate in both symptomatic and asymptomatic patients.
Discussion:
SE represents an effective tool for the risk stratification of patients with previous CABG independently of the presence of symptoms suggestive of ischemic origin.
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