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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jun 24, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Drosophila in asthma research.

Thomas Roeder¹, Kerstin Isermann, Michael Kabesch

¹Department of Zoophysiology, Christian Albrechts University Kiel, Kiel, Germany. troeder@zoologie.uni-kiel.de

American Journal of Respiratory and Critical Care Medicine

|April 4, 2009

Summary

The fruit fly, Drosophila, offers a valuable model for understanding asthma genetics. Its airway epithelium shows expression and regulation of asthma-related genes, aiding in asthma research.

Area of Science:

Genetics
Immunology
Model Organisms

Background:

Asthma research has identified numerous susceptibility genes.
Genome-wide association studies are rapidly expanding the list of candidate genes.
Understanding gene function in asthma requires tractable model organisms.

Purpose of the Study:

To explore the utility of Drosophila melanogaster as a model system for asthma research.
To identify and analyze homologs of human asthma-susceptibility genes in Drosophila.
To investigate the role of these genes in airway immunity and disease phenotypes within the fly model.

Main Methods:

Comparative genomics to identify Drosophila homologs of human asthma-susceptibility genes.
Analysis of gene expression in Drosophila airway epithelium.

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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

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Published on: April 13, 2010

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Investigating gene regulation in response to airway infection in Drosophila.

Main Results:

Orthologs for most human asthma-susceptibility genes were found in Drosophila, excluding those related to adaptive immunity.
Many identified asthma-related genes are expressed in the Drosophila airway epithelium.
Some genes showed regulation upon airway infection, suggesting a role in immunity and asthma-like phenotypes.

Conclusions:

Drosophila serves as a complementary model system for studying asthma genetics and function.
The fruit fly's airway epithelium is a relevant site for investigating asthma-related gene roles.
High-throughput functional studies in Drosophila can advance our understanding of complex diseases like asthma.