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Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...

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Related Experiment Video

Updated: Jun 24, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Renal replacement therapy in critically ill patients.

Anne K H Leung1, W W Yan

  • 1Department of Anaesthesia and Operation Theatre Service, Queen Elizabeth Hospital, Hong Kong. leungkha@ha.org.hk

Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi
|April 4, 2009
PubMed
Summary

Acute renal failure in critically ill patients is common with high mortality. Renal replacement therapy (RRT) effectiveness is linked to dose, with 35 mL/kg/h being standard, though ongoing trials may change this.

Related Experiment Videos

Last Updated: Jun 24, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Renal Replacement Therapy

Background:

  • Acute renal failure (ARF) is prevalent in critically ill patients, carrying a mortality rate up to 60%.
  • Practices and outcomes of renal replacement therapy (RRT) vary significantly across studies.
  • The Acute Dialysis Quality Initiative's classification aids in understanding ARF epidemiology and outcomes.

Purpose of the Study:

  • To update information on renal replacement therapy for critically ill patients.
  • To review current treatment strategies and outcomes for acute renal failure in critical care.

Main Methods:

  • Comprehensive literature search of Medline and PubMed up to June 2008.
  • Inclusion of original studies, literature reviews, and book chapters.
  • Synthesis of data to provide an overview of RRT in critically ill patients.

Main Results:

  • A unified classification (RIFLE) improves the description of ARF epidemiology and outcomes.
  • A direct relationship between dialysis dose and survival exists, with 35 mL/kg/h as a benchmark, though recent trials challenge this.
  • Citrate as an anticoagulant in RRT can improve circuit patency and reduce bleeding but has complex setup and metabolic limitations.

Conclusions:

  • The RIFLE classification accurately describes ARF epidemiology and outcomes in critically ill patients.
  • The standard RRT dose of 35 mL/kg/h requires further validation from ongoing clinical trials.
  • Overcoming challenges with citrate anticoagulation in RRT may be possible with pharmaceutical support.