Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disseminated intravascular coagulation and stroke associated with cervical cancer.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2007
Same author

Early and late recurrence of ischemic lesion on MRI: evidence for a prolonged stroke-prone state?

Neurology·2004
Same author

The hypointense MCA sign.

Neurology·2002
Same author

Pearls and pitfalls in the intensive care management of Guillain-Barré syndrome.

Seminars in neurology·2002
Same author

Continuous arterial spin labeling perfusion magnetic resonance imaging findings in postpartum vasculopathy.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2001
Same author

Predictors of fatal brain edema in massive hemispheric ischemic stroke.

Stroke·2001

Related Experiment Video

Updated: Jun 24, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Evaluating the carotid plaque: going beyond stenosis.

J A Chalela1

  • 1Medical University of South Carolina, Charleston, SC 29425, USA. chalela@musc.edu

Cerebrovascular Diseases (Basel, Switzerland)
|April 4, 2009
PubMed
Summary

Identifying vulnerable carotid plaque using imaging and biochemical markers offers a promising strategy for preventing ischemic stroke. This approach moves beyond traditional stenosis assessment to better identify high-risk patients.

Area of Science:

  • Vascular Neurology
  • Cardiovascular Imaging
  • Biomarkers

Background:

  • Carotid artery disease is a significant cause of ischemic stroke.
  • Traditional management focuses on high-grade carotid stenosis in symptomatic individuals.
  • Emerging research highlights vulnerable plaque identification as a key preventive strategy for both symptomatic and asymptomatic patients.

Purpose of the Study:

  • To review current imaging modalities and biochemical markers for identifying vulnerable carotid plaques.
  • To discuss the clinical applications of these tools in stroke prevention.

Main Methods:

  • Literature review of key references on vulnerable carotid plaque identification.
  • Analysis of imaging techniques including ultrasound, CT, and MRI.

More Related Videos

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Related Experiment Videos

Last Updated: Jun 24, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

  • Evaluation of biochemical markers related to atherosclerosis, inflammation, and thrombosis.

    • Main Results:

    • Carotid ultrasound, CT, and MRI can detect features of vulnerable plaques.
    • Carotid ultrasound is a well-studied, accessible, and interpretable imaging modality.
    • Serum markers of atherosclerosis, inflammation, and thrombosis aid in vulnerable plaque identification.

    Conclusions:

    • A multimodal approach combining imaging and biochemical analysis is promising for identifying vulnerable carotid plaques.
    • Beyond stenosis degree, imaging and biochemical findings hold significant clinical importance for stroke risk stratification.