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Vasculitic IgA nephropathy: prognosis and outcome
Tanya Pankhurst1, Julia Lepenies, Peter Nightingale
1Department of Immunity and Infection, Institute of Biomedical Research Medical School, University of Birmingham, Edgbaston Birmingham, UK. t.pankhurst@bham.ac.uk
Nephron. Clinical Practice
|April 4, 2009
Summary
Prognostic factors for vasculitic IgA nephropathy include presenting renal function, blood pressure, and biopsy-confirmed chronic damage. Immunosuppression may be beneficial for some patients with this kidney condition.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Vasculitic glomerulonephritis is a feature of IgA nephropathy and Henoch-Schonlein purpura.
- No prior studies have identified prognostic factors in vasculitic IgA nephropathy.
Purpose of the Study:
- To identify prognostic factors in patients with vasculitic IgA nephropathy.
Main Methods:
- Retrospective review of 67 patients with vasculitic IgA nephropathy between 1996 and 2003.
- Analysis of clinical and pathological features at presentation and during follow-up.
Main Results:
- Presenting renal function, blood pressure, and chronic damage on biopsy significantly impacted renal outcomes.
- 84% patient survival and 85% renal survival at 60 months were observed.
- The impact of immunosuppression was difficult to ascertain due to non-comparable groups.
Conclusions:
- Presenting renal function, blood pressure, and biopsy-assessed chronic damage are key prognostic indicators for vasculitic IgA nephropathy.
- Immunosuppressive therapy is recommended for select patients.
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