Association between Endothelial Biomarkers and Arterial Elasticity in Young Adults - The CARDIA Study
Narayanan I Valappil1, David R Jacobs, Daniel A Duprez
1Health Resources and Services Administration, 5600 Fishers Lane, Room 7A-42, Rockville, MD 20857.
Insights
Endothelial dysfunction markers, smoking, and triglycerides are linked to reduced arterial elasticity (large artery elasticity and small artery elasticity) in young adults, indicating early cardiovascular disease risk.
Area of Science:
- Cardiovascular disease research
- Vascular biology
- Preventive cardiology
Background:
- Reduced arterial elasticity and endothelial dysfunction are early indicators of cardiovascular disease in young adults.
- Pulse waveform analysis noninvasively estimates large artery elasticity (LAE) and small artery elasticity (SAE).
Purpose of the Study:
- To assess the associations between LAE and SAE and markers of endothelial dysfunction.
- To investigate the relationship between arterial elasticity and cardiovascular risk factors in young adults.
Main Methods:
- Utilized data from the Coronary Artery Risk Development in Young Adults (CARDIA) study.
- Assessed arterial elasticity and circulating levels of P-selectin and soluble intercellular adhesion molecule 1 (sICAM-1).
- Adjusted for relevant covariates including height, BMI, age, heart rate, and blood pressure.
Main Results:
- Microalbuminuria was associated with lower SAE (p=0.008).
- Higher P-selectin levels were associated with lower LAE (p=0.004).
- Plasma triglycerides and smoking were inversely related to LAE and SAE, respectively.
Conclusions:
- Biomarkers for endothelial dysfunction are associated with impaired LAE and SAE in young adults.
- Smoking and triglycerides are also significant factors associated with reduced arterial elasticity.
Background:
Reduced arterial elasticity and endothelial dysfunction both may indicate early cardiovascular (CV) disease in young adults. Pulse waveform analysis estimates large (LAE) and small (SAE) artery elasticity noninvasively. We assessed the associations between LAE and SAE and markers of endothelial dysfunction and CV risk factors.
Methods:
The Coronary Artery Risk Development in Young Adults (CARDIA) assessed arterial elasticity and other characteristics cross-sectionally in 389 men and 381 women aged 27-42 years in 1995 (CARDIA year 10) and circulating levels of P-selectin and soluble intercellular adhesion molecule 1 (sICAM-1) in 2000. We adjusted for variables included in the estimation of arterial elasticity (year 10 height, body mass index, age, heart rate, and blood pressure) and other year 10 characteristics.
Results:
Mean adjusted SAE was 8.5 vs. 7.6 ml/mmHg x100 in those with urine albumin/creatinine ratio 25; p(trend) =0.008). Mean LAE was 25.6 vs. 24.2 ml/mmHg x10 in the lowest vs. highest quintile of P-selectin (p(trend) =0.004). sICAM-1 was unrelated to either LAE or SAE. Plasma triglycerides were inversely related to LAE (p(trend) =0.029). Cigarette smokers had lower SAE than nonsmokers (p(trend) = 0.009).
Conclusion:
In addition to smoking and triglycerides, biomarkers for endothelial dysfunction were associated with impaired LAE and SAE in young adults.
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