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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Updated: May 5, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Pathophysiology of psoriasis.

J J Voorhees

    Annual Review of Medicine
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Psoriasis involves benign but unrestricted epithelial cell growth. Understanding its molecular causes, including cell surface interactions and metabolic pathways, could reveal broader insights into growth regulation.

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    Area of Science:

    • Dermatology
    • Molecular Biology
    • Cell Biology

    Background:

    • Psoriasis is characterized by benign, uncontrolled epithelial cell proliferation.
    • The molecular mechanisms underlying this unregulated growth require further elucidation.

    Purpose of the Study:

    • To explore the role of cell surface interactions in psoriasis pathophysiology.
    • To investigate the involvement of cyclic nucleotides, arachidonic acid-prostaglandin metabolism, and polyamines in psoriasis.
    • To gain insights into general mechanisms of growth regulation through the study of psoriasis.

    Main Methods:

    • Review of existing literature on psoriasis molecular pathophysiology.
    • Analysis of the roles of specific cellular and metabolic components.

    Main Results:

    • The study discusses the molecular pathophysiology of psoriasis, focusing on epithelial growth.
    • It highlights key areas for further investigation, including cell surface, cyclic nucleotides, prostaglandin metabolism, and polyamines.

    Conclusions:

    • A deeper understanding of these factors in psoriasis may clarify the disease's mechanisms.
    • This research could provide generalizable clues for understanding growth regulation.