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Soluble Triggering Receptor Expressed on Myeloid cells-1 in bronchoalveolar lavage fluid is not predictive for

Guy J Oudhuis1, Judith Beuving, Dennis Bergmans

  • 1Department of Medical Microbiology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

Intensive Care Medicine
|April 4, 2009
PubMed
Abstract

Insights

Soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM-1) in bronchoalveolar lavage fluid (BALF) showed higher concentrations in ventilator-associated pneumonia (VAP) patients. However, sTREM-1 levels were not discriminative enough for VAP diagnosis.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Soluble Triggering Receptor Expressed on Myeloid cells-1 (sTREM-1) is a recognized biomarker for sepsis.
  • Limited research exists on sTREM-1's utility in diagnosing ventilator-associated pneumonia (VAP).

Purpose of the Study:

  • To assess the diagnostic value of sTREM-1 in bronchoalveolar lavage fluid (BALF) for VAP in intensive care unit (ICU) patients.
  • To determine if sTREM-1 can serve as a rapid diagnostic marker for VAP.

Main Methods:

  • Quantitative sandwich enzyme immunoassay used to measure sTREM-1 in 240 BALF samples.
  • VAP diagnosis confirmed by specific microbiological criteria (intracellular organisms or bacterial culture counts).
  • Independent assessment by blinded researchers to avoid bias.

Main Results:

  • Mean sTREM-1 concentration was significantly elevated in BALF from VAP patients compared to non-VAP patients.
  • The area under the receiver-operating characteristic curve (AUC) was 0.58, indicating limited discriminatory power.
  • Statistical significance was observed (P = 0.04), but the clinical utility is questionable.

Conclusions:

  • The sTREM-1 assay in BALF may not be a sufficiently discriminative biomarker for diagnosing VAP.
  • Further research may be needed to explore other biomarkers or combinations for VAP diagnosis.

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