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Updated: Jun 24, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
New benzamide derivatives and NO production inhibitory compounds from Limonia acidissima
Ki Hyun Kim1, Il Kyun Lee, Kyung Ran Kim
1Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University, Suwon, Korea.
Abstract:
Three new benzamide derivatives, N-{[ P-(3,7-dimethyl-6 R,7-dihydroxy-4 R-octadecanoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (1), N-{[ P-(3,7-dimethyl-6 R,7-dihydroxy-4 R-9'''( E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (2), and N-{[ P-(3,7-dimethyl-6 R,7-epoxy-4 R-9'''( E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (3), together with 10 known compounds (4-13), were isolated from the bark of Limonia acidissima. The structures of these new compounds were determined through spectral analyses, including extensive 2D NMR data. Among the isolates, 13 alpha,14 beta,17 alpha-lanosta-7,9,24-triene-3 beta,16 alpha-diol (8), 4-methoxy-1-methyl-2(1 H)-quinolinone (10), and 13 alpha,14 beta,17 alpha-lanosta-7,24-diene-3 beta,11 beta,16 alpha-triol (13) potently inhibited nitric oxide (NO) production in microglia cells.
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