[Selenium deficiency and oxidative stress in asymptomatic HIV1-infected patients in Côte d'Ivoire]

The aim of the present study was to evaluate the oxidative stress and selenium status and the antioxidant capacity of asymptomatic HIV1-infected patients in Côte d'Ivoire. This study involved 30 asymptomatic HIV1-infected patients, aged from 18 to 50 years old, selected in CIRBA (Centre Intégré de Recherche Bioclinique d'Abidjan). They were not yet treated by antiretroviral medicine. Oxidative stress indicators MDA (malondialdehyde) and AOPP (advanced oxidation protein products) were measured respectively by spectrofluorimetric method and spectrophotometric method. Selenium, vitamin E and vitamin A concentrations were evaluated according to the HPLC method. Our results show that all patients were deficient in selenium (0.58 +/- 0.12 micromol/L vs 1.80 +/- 0.31 micromol/L, p < 0.0001). Patient Vitamin E plasma level (27.47 +/- 8.33 micromol/L vs 19.10 +/- 5.33 micromol/L, p < 0.0001) and oxidative stress indicators MDA (3.32 +/- 0.40 nmol/L vs 0.99 +/- 0.26 nmol/L p < 0.0001) and AOPP (62.49 +/- 13.75 micromol/L vs 39.49 +/- 21.27 micromol/L p < 0.0001) were significantly higher in the infected group. These results reveal a severe selenium deficiency and oxidative stress in VIH1-infected asymptomatic Persons in Côte d'Ivoire.