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Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass
Published on: May 27, 2022
Biologically active cannabinoids from high-potency Cannabis sativa
Mohamed M Radwan1, Mahmoud A Elsohly, Desmond Slade
1Department of Pharmaceutics, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA.
Journal of Natural Products
|April 7, 2009
Summary
Nine novel cannabinoids were identified from high-potency Cannabis sativa. Some compounds showed significant antibacterial, antifungal, and antileishmanial activities, highlighting their therapeutic potential.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Cannabis sativa is a source of diverse bioactive compounds.
- Understanding the chemical diversity of cannabis is crucial for exploring its therapeutic applications.
Purpose of the Study:
- To isolate and characterize novel cannabinoids from a high-potency Cannabis sativa variety.
- To evaluate the biological activities of the isolated compounds.
Main Methods:
- Isolation of nine new cannabinoids and one known sterol derivative.
- Structure elucidation using 1D and 2D NMR spectroscopy, GC-MS, and HRESIMS.
- Assessment of antibacterial, antifungal, and antileishmanial activities.
Main Results:
- Nine novel cannabinoids, including acetoxycannabichromene, hydroxycannabichromene, and hydroxycannabichromane derivatives, were identified.
- A known sterol, beta-sitosterol-3-O-beta-d-glucopyranosyl-6'-acetate, was isolated for the first time from cannabis.
- Compounds 6 and 7 exhibited significant antibacterial and antifungal activities, respectively.
- Compound 5 demonstrated potent antileishmanial activity.
Conclusions:
- The study successfully identified novel cannabinoids from Cannabis sativa.
- Specific isolated compounds possess promising antimicrobial and antileishmanial properties.
- These findings contribute to the understanding of cannabis phytochemistry and its potential medicinal uses.
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