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Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
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Ustekinumab.

Juliane Weber1, Susan J Keam

  • 1Wolters Kluwer Health | Adis, 41 Centorian Drive, Mairangi Bay, North Shore 0754, Auckland, New Zealand.

Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
|April 7, 2009
PubMed
Summary
This summary is machine-generated.

Ustekinumab effectively treats moderate to severe plaque psoriasis by targeting IL-12 and IL-23 cytokines. Clinical trials show significant PASI 75 improvements and sustained symptom control with ustekinumab therapy.

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Area of Science:

  • Immunology
  • Dermatology
  • Rheumatology

Background:

  • Psoriasis is an inflammatory condition linked to IL-12 and IL-23.
  • Ustekinumab is a monoclonal antibody targeting these cytokines.

Purpose of the Study:

  • To evaluate ustekinumab's efficacy and safety in moderate to severe plaque psoriasis.
  • To assess ustekinumab's impact on psoriatic arthritis and quality of life.

Main Methods:

  • Phase III trials with subcutaneous ustekinumab (45 or 90 mg) vs. placebo.
  • Phase II trial assessing ustekinumab in plaque psoriasis and psoriatic arthritis.
  • Efficacy measured by PASI 75, physician's global assessment, ACR criteria, and quality of life indices.

Main Results:

  • Significantly more ustekinumab recipients achieved PASI 75 at 12 weeks compared to placebo.
  • Symptom control was maintained up to 76 weeks with maintenance therapy.
  • Improvements were observed in arthritis symptoms and health-related quality of life.

Conclusions:

  • Ustekinumab demonstrates significant efficacy in treating plaque psoriasis and psoriatic arthritis.
  • The treatment shows sustained efficacy and is generally well-tolerated.
  • Ustekinumab improves both skin and joint symptoms, enhancing quality of life.