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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Cell-mediated Immune Responses01:40

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Overview
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Highly Resolved Intravital Striped-illumination Microscopy of Germinal Centers
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The Germinal centre-derived lymphomas seen through their cellular microenvironment.

Antonino Carbone1, Annunziata Gloghini, Antonello Cabras

  • 1Department of Pathology and Laboratory and Transfusion Medicine, Istituto Nazionale Tumori, Milano, Italy. antonino.carbone@istitutotumori.mi.it

British Journal of Haematology
|April 7, 2009
PubMed
Summary

The tumor microenvironment significantly impacts germinal center-derived lymphomas. Understanding these cellular interactions aids in diagnosing and predicting tumor progression in lymphomas.

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Area of Science:

  • Immunology
  • Oncology
  • Pathology

Background:

  • Lymph nodes are complex tissues with organized cellular populations.
  • Germinal centers (GCs) are crucial for B cell physiology and are implicated in malignancy.
  • GC-derived lymphomas' progression may be linked to the tumor microenvironment.

Purpose of the Study:

  • To review GC-derived lymphomas, including follicular lymphoma, Hodgkin lymphoma, and angioimmunoblastic T-cell lymphoma.
  • To explore the role of the cellular microenvironment in these lymphomas.
  • To identify potential surrogate markers for diagnosis and progression.

Main Methods:

  • Review of gene expression profiling studies in GC-derived lymphomas.
  • Immunohistological analysis of lymphoma biopsy samples.
  • Examination of the integrated cellular microenvironment and key molecules.

Main Results:

  • Patient survival in GC-derived lymphomas may correlate with specific gene expression signatures in non-malignant immune cells.
  • Tumor progression and biological behavior are influenced by the tumor microenvironment.
  • Specific microenvironmental components and molecules play roles in tumor development.

Conclusions:

  • The tumor microenvironment is a critical factor in GC-derived lymphomas.
  • Identifying microenvironmental markers can aid in lymphoma diagnosis and prognosis.
  • Further research into key molecules involved in tumor development is warranted.