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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Bioactive cell-hydrogel microcapsules for cell-based drug delivery.

Gorka Orive1, María De Castro, Hyun-Joon Kong

  • 1Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, Vitoria-Gasteiz, Spain.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|April 7, 2009
PubMed
Summary

Biomimetic cell-hydrogel capsules enhance long-term drug delivery and mechanical stability. This novel system provides sustained erythropoietin release for 300 days without immunosuppression.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Cell encapsulation faces challenges in long-term drug release and mechanical stability of devices.
  • Current calcium-alginate beads exhibit weak in vivo stability and lack biomimicry.
  • Inactive biomaterials and inert scaffolds fail to replicate the physiological cell environment.

Purpose of the Study:

  • To design biomimetic cell-hydrogel capsules for improved in vivo cell functionality and capsule mechanical stability.
  • To investigate the potential of cell adhesion peptides and bimodal molecular weight distributions in enhancing capsule performance.
  • To establish a novel system for sustained, controlled drug delivery from immobilized cells.

Main Methods:

  • Fabrication of biomimetic capsules by coupling arginine glycine aspartic acid (RGD) peptide to alginate.
  • Utilizing an alginate mixture with a bimodal molecular weight distribution for capsule formulation.
  • In vivo assessment of long-term functionality and drug release from encapsulated cells.

Main Results:

  • Biomimetic capsules promoted cell adhesion, enhancing mechanical stability of the cell-polymer system.
  • Significantly prolonged in vivo long-term functionality and drug release of encapsulated cells.
  • Achieved sustained erythropoietin delivery for 300 days without immunosuppressive protocols.
  • Demonstrated controlled in vitro and in vivo drug delivery by managing cell dose within capsules.

Conclusions:

  • Biomimetic cell-hydrogel capsules offer a promising microenvironment for de novo drug delivery.
  • The developed system overcomes limitations of traditional cell encapsulation for long-term therapeutic applications.
  • This approach enables sustained drug release and improved device stability, paving the way for advanced cell-based therapies.