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Complex movement disorders in primary antiphospholipid syndrome: a case report
Miryam Carecchio1, Cristoforo Comi, Claudia Varrasi
1Department of Neurology, Amedeo Avogadro University, Corso Mazzini 18, 28100 Novara, Italy. mcarecchio@gmail.com
Journal of the Neurological Sciences
|April 7, 2009
Summary
Antiphospholipid syndrome (APS) can cause unusual neurological symptoms like movement disorders, even in older adults. Early diagnosis is key, as this case highlights APS as a potential cause of complex hyperkinetic syndromes.
Area of Science:
- Neurology
- Immunology
- Rheumatology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune condition linked to thrombosis and pregnancy issues.
- Neurological manifestations, including movement disorders, can occur in APS patients.
Observation:
- A 79-year-old woman presented with progressive agitation and insomnia, followed by acute hyperkinetic syndrome (chorea, dystonia, dyskinesias, speech impairment).
- Brain MRI revealed ischemic lesions, including a cortical lesion in the left posterior temporal lobe.
Findings:
- Elevated anticardiolipin (aCL) and anti-beta(2) glycoprotein-I antibodies, along with positive Lupus Anticoagulant (LAC), confirmed APS.
- The patient was diagnosed with primary APS, despite no prior thrombotic events.
Implications:
- This case emphasizes APS as a differential diagnosis for unexplained movement disorders in the elderly.
- Recognizing APS is crucial for timely intervention and management of neurological complications.
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