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Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species
Essam Abdel-Sattar1, Naglaa G Shehab, Chikara Ichino
1Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia. abdelsattar@yahoo.com
Abstract:
Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC(50) 1.01 microg/ml) followed by caratuberside C (IC(50) 1.85 microg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity.
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