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Updated: Jun 24, 2026
08:22
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
Generating new blood flow: integrating developmental biology and tissue engineering
Guido Krenning1, Jan-Renier A J Moonen, Marja J A van Luyn
1Department of Pathology & Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein, The Netherlands.
Trends in Cardiovascular Medicine
|April 7, 2009
Summary
This review explores using progenitor cells and advanced biomaterials for vascular tissue engineering. The goal is to create bioartificial blood vessels by guiding cell differentiation solely through smart biomaterial design.
Area of Science:
- Biomaterials Science
- Developmental Biology
- Regenerative Medicine
Background:
- Vascular tissue engineering seeks to restore blood flow using artificial scaffolds seeded with cells.
- Progenitor cells offer promise due to their differentiation potential and longevity.
- Current approaches require integrating developmental biology insights with biomaterial advancements.
Purpose of the Study:
- To review a novel vascular tissue engineering approach.
- To integrate developmental biology principles with biomaterial design.
- To propose a new paradigm for small-diameter blood vessel creation.
Main Methods:
- Focus on developmental processes regulating progenitor cell differentiation.
- Leverage progenitor cell plasticity.
- Incorporate advances in biomaterial design.
Main Results:
- Developmental biology insights can guide biomaterial design.
- Biomaterials can instruct progenitor cell differentiation and tissue organization.
- A novel engineering paradigm for small-diameter blood vessels is proposed.
Conclusions:
- Integrating developmental biology and material science is powerful for vascular tissue engineering.
- Biomaterial-instructed progenitor cell differentiation offers a promising approach.
- This strategy advances the creation of bioartificial blood vessels.
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